Using nanoparticles for drug delivery in cancer treatment: our major results published in PLoS ONE
One of the main works of Joan Comenge’s doctorate in our group has focused on the study of drug delivery using nanoparticles as carriers, specifically for cancer treatment. The work started up on the patent previously developed by Víctor Puntes and collaborators, to refine and test gold nanoparticles where the chosen anti-cancer drug (cisplatin) is linked to them by a pH-sensitive link resulting from a careful multi-step bioconjugation protocol.
Developed through a long interdisciplinary collaboration with research groups from the Santiago de Compostela University, the University of Valencia and the Sant Pau Hospital, the results on the analysis of this drug delivery system, including in vitro and in vivo (mice) bio-distribution studies, has recently been published in PLoS ONE: “Detoxifying Antitumoral Drugs via Nanoconjugation: The Case of Gold Nanoparticles and Cisplatin”.
The paper presents the success of the specially designed nanocarriers in decreasing the treatment toxicity, essentially by driving the drug more efficiently to its target, the tumor, and thus avoiding undesired side effects. But it is also geared to present and advance the field of nanocarriers for delivering platinum-based drugs more broadly. For example, an editorial published almost simultaneously, “Nanoparticles: the future for platinum drugs or a research red herring?” (by N. Wheate, Nanomedicine), did a great job in summarizing the hopes and challenges that lie in this type of cancer treatment approach. And notably, our work on delivering cisplatin with gold nanoparticles addresses all the points raised, framing the strategy and its results on a more general, and more useful, pharmacological perspective.
J. Comenge, C. Sotelo, F. Romero, O. Gallego, A. Barnadas, T. García-Caballero Parada, F. Domingues and V. Puntes (2012). Detoxifying Antitumoral Drugs via Nanoconjugation: The Case of Gold Nanoparticles and Cisplatin, PLoS ONE 7(10): e47562
(open access article)